Highlighted Publications
Microbial imprinting of the airway epithelium
van de Ven, J. J. I., Amatngalim, G. D., Garssen, J., Netea, M. G., & Perdijk, O.
Cell Reports, 45(8), Article 117705 (2026) [Link]
van de Ven, J. J. I., Amatngalim, G. D., Garssen, J., Netea, M. G., & Perdijk, O.
Cell Reports, 45(8), Article 117705 (2026) [Link]
In this review, we discuss this emerging concept of microbial imprinting of the airway epithelium and propose a conceptual framework comprised of four categories: altered differentiation, tolerance, priming and trained immunity. We also highlight how understanding these long-term epithelial adaptations may open new avenues for preventing and treating inflammatory airway diseases.
Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood
Perdijk, O., Butler, A., Macowan, M., Chatzis, R., Bulanda, E., Grant, R. D., Harris, N. L., Wypych, T. P., & Marsland, B. J.
Immunity, 57(8), 1939-1954.e7 (2024) [Link]
Perdijk, O., Butler, A., Macowan, M., Chatzis, R., Bulanda, E., Grant, R. D., Harris, N. L., Wypych, T. P., & Marsland, B. J.
Immunity, 57(8), 1939-1954.e7 (2024) [Link]
We identified a novel a novel mechanism through which early-life antibiotics use impacts on the airway epithelium and predisposes mice to allergy into adulthood. This work received attention from international news stations and newspapers, including the NRC and Herald-Sun, main international news outlets (e.g. Sky news, ABC news and 7-news) and was highlighted in Nature Reviews Immunology (Bird et al, 2024) and Immunity (Ionescu et al, 2024).
The microbiome: an integral player in immune homeostasis and inflammation in the respiratory tract
Perdijk, O., Azzoni, R., & Marsland, B. J.
Physiological Reviews, 104(2), 835-879 (2024) [Link]
Perdijk, O., Azzoni, R., & Marsland, B. J.
Physiological Reviews, 104(2), 835-879 (2024) [Link]
In this comprehensive review we highlight the role of the gut and lung microbiome in modulating immune responses in the respiratory tract. The review discusses preclinical and clinical studies and highlight the mechanisms of action through which microbes’ impact on respiratory health.
All Publications
Microbial imprinting of the airway epithelium
van de Ven, J. J. I., Amatngalim, G. D., Garssen, J., Netea, M. G., & Perdijk, O.
Cell Reports, 45(8), Article 117705 (2026) [Link]
van de Ven, J. J. I., Amatngalim, G. D., Garssen, J., Netea, M. G., & Perdijk, O.
Cell Reports, 45(8), Article 117705 (2026) [Link]
Long-lived IgE plasma cells persist in secondary lymphoid tissues using a navitoclax-sensitive survival program
Ding, Z., Adam, W.-V., Downling, M. R., Dvorscek, A. R., Pitt, C., Mulder, J., O'Donnell, K., McKenzie, C., Karaviotis, A. B., Scrofani, J., Perdijk, O., Hill, D. L., Quast, I., Tarlinton, D. M., Allen, C. D. C., & Robinson, M. J.
Immunity, 58(11), 2704-2716.e4 (2025) [Link]
Ding, Z., Adam, W.-V., Downling, M. R., Dvorscek, A. R., Pitt, C., Mulder, J., O'Donnell, K., McKenzie, C., Karaviotis, A. B., Scrofani, J., Perdijk, O., Hill, D. L., Quast, I., Tarlinton, D. M., Allen, C. D. C., & Robinson, M. J.
Immunity, 58(11), 2704-2716.e4 (2025) [Link]
Helminth infection driven gastrointestinal hypermotility is independent of eosinophils and mediated by alterations in smooth muscle instead of enteric neurons
Wang, H., Barry, K., Zaini, A., Coakley, G., Moyat, M., Daunt, C. P., Wickramasinghe, L. C., Azzoni, R., Chatzis, R., Yumnam, B., Camberis, M., Le Gros, G., Perdijk, O., Foong, J. P. P., Bornstein, J. C., Marsland, B. J., & Harris, N. L.
PLoS Pathogens, 20(8), Article e1011766 (2024) [Link]
Wang, H., Barry, K., Zaini, A., Coakley, G., Moyat, M., Daunt, C. P., Wickramasinghe, L. C., Azzoni, R., Chatzis, R., Yumnam, B., Camberis, M., Le Gros, G., Perdijk, O., Foong, J. P. P., Bornstein, J. C., Marsland, B. J., & Harris, N. L.
PLoS Pathogens, 20(8), Article e1011766 (2024) [Link]
Neuroimmunology of the Lung
Azzoni, R., Perdijk, O., Harris, N. L., & Marsland, B. J.
Annual Review of Immunology, 42(1), 57-81 (2024) [Link]
Azzoni, R., Perdijk, O., Harris, N. L., & Marsland, B. J.
Annual Review of Immunology, 42(1), 57-81 (2024) [Link]
The microbiome: an integral player in immune homeostasis and inflammation in the respiratory tract
Perdijk, O., Azzoni, R., & Marsland, B. J.
Physiological Reviews, 104(2), 835-879 (2024) [Link]
Perdijk, O., Azzoni, R., & Marsland, B. J.
Physiological Reviews, 104(2), 835-879 (2024) [Link]
Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood
Perdijk, O., Butler, A., Macowan, M., Chatzis, R., Bulanda, E., Grant, R. D., Harris, N. L., Wypych, T. P., & Marsland, B. J.
Immunity, 57(8), 1939-1954.e7 (2024) [Link]
Perdijk, O., Butler, A., Macowan, M., Chatzis, R., Bulanda, E., Grant, R. D., Harris, N. L., Wypych, T. P., & Marsland, B. J.
Immunity, 57(8), 1939-1954.e7 (2024) [Link]
Microbial regulation of intestinal motility provides resistance against helminth infection
Moyat, M., Lebon, L., Perdijk, O., Wickramasinghe, L. C., Zaiss, M. M., Mosconi, I., Volpe, B., Guenat, N., Shah, K., Coakley, G., Bouchery, T., & Harris, N. L.
Mucosal Immunology, 15(6), 1283-1295 (2022) [Link]
Moyat, M., Lebon, L., Perdijk, O., Wickramasinghe, L. C., Zaiss, M. M., Mosconi, I., Volpe, B., Guenat, N., Shah, K., Coakley, G., Bouchery, T., & Harris, N. L.
Mucosal Immunology, 15(6), 1283-1295 (2022) [Link]
Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation
Trompette, A., Pernot, J., Perdijk, O., Alqahtani, R. A. A., Domingo, J. S., Camacho-Muñoz, D., Wong, N. C., Kendall, A. C., Wiederkehr, A., Nicod, L. P., Nicolaou, A., von Garnier, C., Ubags, N. D. J., & Marsland, B. J.
Mucosal Immunology, 15(5), 908-926 (2022) [Link]
Trompette, A., Pernot, J., Perdijk, O., Alqahtani, R. A. A., Domingo, J. S., Camacho-Muñoz, D., Wong, N. C., Kendall, A. C., Wiederkehr, A., Nicod, L. P., Nicolaou, A., von Garnier, C., Ubags, N. D. J., & Marsland, B. J.
Mucosal Immunology, 15(5), 908-926 (2022) [Link]
Microbial metabolism of l-tyrosine protects against allergic airway inflammation
Wypych, T. P., Pattaroni, C., Perdijk, O., Yap, C., Trompette, A., Anderson, D., Creek, D. J., Harris, N. L., & Marsland, B. J.
Nature Immunology, 22(3), 279-286 (2021) [Link]
Wypych, T. P., Pattaroni, C., Perdijk, O., Yap, C., Trompette, A., Anderson, D., Creek, D. J., Harris, N. L., & Marsland, B. J.
Nature Immunology, 22(3), 279-286 (2021) [Link]
Plasmacytoid dendritic cell and myeloid dendritic cell function in ageing: A comparison between elderly and young adult women
van Splunter, M., Perdijk, O., Fick-Brinkhof, H., Floris-Vollenbroek, E. G., Meijer, B., Brugman, S., Savelkoul, H. F. J., van Hoffen, E., & Joost van Neerven, R. J.
PLoS One, 14(12), Article e0225825 (2019) [Link]
van Splunter, M., Perdijk, O., Fick-Brinkhof, H., Floris-Vollenbroek, E. G., Meijer, B., Brugman, S., Savelkoul, H. F. J., van Hoffen, E., & Joost van Neerven, R. J.
PLoS One, 14(12), Article e0225825 (2019) [Link]
Sialyllactose and galactooligosaccharides promote epithelial barrier functioning and distinctly modulate microbiota composition and short chain fatty acid production in vitro
Perdijk, O., Baarlen, P. V., Fernandez-Gutierrez, M. M., Brink, E. V., Schuren, F. H. J., Brugman, S., Savelkoul, H. F. J., Kleerebezem, M., & Neerven, R. J. J. V.
Frontiers in Immunology, 10, Article 94 (2019) [Link]
Perdijk, O., Baarlen, P. V., Fernandez-Gutierrez, M. M., Brink, E. V., Schuren, F. H. J., Brugman, S., Savelkoul, H. F. J., Kleerebezem, M., & Neerven, R. J. J. V.
Frontiers in Immunology, 10, Article 94 (2019) [Link]
The microbiome: toward preventing allergies and asthma by nutritional intervention
Perdijk, O., & Marsland, B. J.
Current Opinion in Immunology, 60, 10-18 (2019) [Link]
Perdijk, O., & Marsland, B. J.
Current Opinion in Immunology, 60, 10-18 (2019) [Link]
Induction of human tolerogenic dendritic cells by 3′-sialyllactose via TLR4 is explained by LPS contamination
Perdijk, O., Joost Van Neerven, R. J., Meijer, B., Savelkoul, H. F. J., & Brugman, S.
Glycobiology, 28(3), 126-130 (2018) [Link]
Perdijk, O., Joost Van Neerven, R. J., Meijer, B., Savelkoul, H. F. J., & Brugman, S.
Glycobiology, 28(3), 126-130 (2018) [Link]
Cow's milk and immune function in the respiratory tract: Potential mechanisms
Perdijk, O., van Splunter, M., Savelkoul, H. F. J., Brugman, S., & van Neerven, R. J. J.
Frontiers in Immunology, 9, Article 143 (2018) [Link]
Perdijk, O., van Splunter, M., Savelkoul, H. F. J., Brugman, S., & van Neerven, R. J. J.
Frontiers in Immunology, 9, Article 143 (2018) [Link]
Bovine Lactoferrin Modulates Dendritic Cell Differentiation and Function
Perdijk, O., Neerven, R. J. J. V., den Brink, E. V., Savelkoul, H. F. J., & Brugman, S.
Nutrients, 10(7), Article 848 (2018) [Link]
Perdijk, O., Neerven, R. J. J. V., den Brink, E. V., Savelkoul, H. F. J., & Brugman, S.
Nutrients, 10(7), Article 848 (2018) [Link]
The oligosaccharides 6'-sialyllactose, 2'-fucosyllactose or galactooligosaccharides do not directly modulate human dendritic cell differentiation or maturation
Perdijk, O., van Neerven, R. J. J., van den Brink, E., Savelkoul, H. F. J., & Brugman, S.
PLoS One, 13(7), Article e0200356 (2018) [Link]
Perdijk, O., van Neerven, R. J. J., van den Brink, E., Savelkoul, H. F. J., & Brugman, S.
PLoS One, 13(7), Article e0200356 (2018) [Link]
Bovine lactoferrin enhances TLR7-mediated responses in plasmacytoid dendritic cells in elderly women: Results from a nutritional intervention study with bovine lactoferrin, GOS and Vitamin D
Van Splunter, M., Perdijk, O., Fick-Brinkhof, H., Feitsma, A. L., Floris-Vollenbroek, E. G., Meijer, B., Brugman, S., Savelkoul, H. F. J., Van Hoffen, E., & Van Neerven, R. J. J.
Frontiers in Immunology, 9, Article 2677 (2018) [Link]
Van Splunter, M., Perdijk, O., Fick-Brinkhof, H., Feitsma, A. L., Floris-Vollenbroek, E. G., Meijer, B., Brugman, S., Savelkoul, H. F. J., Van Hoffen, E., & Van Neerven, R. J. J.
Frontiers in Immunology, 9, Article 2677 (2018) [Link]
Frontline science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1-/∆7 mice
van Beek, A. A., Hugenholtz, F., Meijer, B., Sovran, B., Perdijk, O., Vermeij, W. P., Brandt, R. M. C., Barnhoorn, S., Hoeijmakers, J. H. J., de Vos, P., Leenen, P. J. M., Hendriks, R. W., & Savelkoul, H. F. J.
Journal of Leukocyte Biology, 101(4), 811-821 (2017) [Link]
van Beek, A. A., Hugenholtz, F., Meijer, B., Sovran, B., Perdijk, O., Vermeij, W. P., Brandt, R. M. C., Barnhoorn, S., Hoeijmakers, J. H. J., de Vos, P., Leenen, P. J. M., Hendriks, R. W., & Savelkoul, H. F. J.
Journal of Leukocyte Biology, 101(4), 811-821 (2017) [Link]
Optimized triton X-114 assisted lipopolysaccharide (LPS) removal method reveals the immunomodulatory effect of food proteins
Teodorowicz, M., Perdijk, O., Verhoek, I., Govers, C., Savelkoul, H. F. J., Tang, Y., Wichers, H., & Broersen, K.
PLoS One, 12(3), e0173778 (2017) [Link]
Teodorowicz, M., Perdijk, O., Verhoek, I., Govers, C., Savelkoul, H. F. J., Tang, Y., Wichers, H., & Broersen, K.
PLoS One, 12(3), e0173778 (2017) [Link]
Mucosal Immune Development in Early Life: Setting the Stage
Brugman, S., Perdijk, O., van Neerven, R. J. J., & Savelkoul, H. F. J.
Archivum Immunologiae et Therapiae Experimentalis, 63, 251-268 (2015) [Link]
Brugman, S., Perdijk, O., van Neerven, R. J. J., & Savelkoul, H. F. J.
Archivum Immunologiae et Therapiae Experimentalis, 63, 251-268 (2015) [Link]
Haptoglobin phenotype prevalence and cytokine profiles during Plasmodium falciparum infection in Dogon and Fulani ethnic groups living in Mali
Perdijk, O., Arama, C., Giusti, P., Maiga, B., Troye-Blomberg, M., Dolo, A., Doumbo, O., Persson, J.-O., & Boström, S.
Malaria Journal, 12, 1-12, Article 432 (2013) [Link]
Perdijk, O., Arama, C., Giusti, P., Maiga, B., Troye-Blomberg, M., Dolo, A., Doumbo, O., Persson, J.-O., & Boström, S.
Malaria Journal, 12, 1-12, Article 432 (2013) [Link]